SpectraDx
Market
Wearable Spectroscopy: SERS, NIR, and Molecular Monitoring
Wearable spectroscopy sensors are advancing fast: SERS patches for sweat biomarkers, NIR glucose devices, and chip-scale spectrometers nearing clinical use.
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Near-Infrared Spectroscopy
NIR Spectroscopy Integration
Connect FOSS, Metrohm, ABB, and Bruker NIR analyzers to clinical and pharmaceutical workflows. SpectraDx automates NIR measurement, calibration management, and regulatory-compliant reporting.
Overview
What is NIR in Clinical Diagnostics?
Near-infrared (NIR) spectroscopy measures light absorption in the 780–2500 nm range — between visible light and mid-infrared. NIR bands arise from overtones and combinations of fundamental molecular vibrations, making NIR especially sensitive to O–H, C–H, and N–H bonds found in biological and pharmaceutical samples.
NIR has unique advantages for clinical applications: it penetrates deeper into tissue than FTIR or Raman, works non-invasively through skin, and instruments can be miniaturized for wearable devices. This enables continuous monitoring — blood glucose, tissue oxygenation, hemoglobin levels — without drawing blood.
The analytical challenge with NIR is that absorption bands are broad and overlapping, requiring chemometric models (PLS, PCR) rather than simple peak identification. SpectraDx manages the model lifecycle — calibration, validation, transfer between instruments — and converts chemometric predictions into clinical results.
Clinical Applications
Blood Glucose Monitoring
Non-invasive continuous glucose measurement through skin using NIR absorption spectroscopy
Tissue Oxygenation
Real-time cerebral and tissue oximetry for surgical monitoring and neonatal care
Blood Analysis
Rapid hemoglobin, hematocrit, and blood component analysis without wet chemistry
Pharmaceutical QC
Raw material identification, content uniformity testing, and at-line process monitoring
Instruments
Supported Instruments
SpectraDx provides modular instrument adapters. Each adapter handles vendor-specific protocols so your clinical workflow stays consistent.
FOSS
DS2500
FOSS Integration Manager SDK for DS2500 and XDS series process and laboratory NIR analyzers.
In Development
Metrohm
NIRS XDS
Vision Air integration via OPC-UA for inline and at-line NIR analysis applications.
Planned
ABB
FTPA2000-260
Process NIR analyzer integration via Modbus TCP and OPC-UA protocols for continuous monitoring.
Planned
Bruker
MPA II
OPUS-based integration for the multipurpose FT-NIR analyzer with fiber optic probes.
Planned
NeoSpectra
Micro
Compact MEMS-based NIR sensor with open SDK — ideal for handheld and embedded clinical devices.
In Development
The Problem
The Software Gap
Instrument vendor software like ISIscan (FOSS), Vision Air (Metrohm), OPUS (Bruker) is designed for research, not clinical deployment.
What vendor software provides
Spectral acquisition and measurement
Data visualization and analysis
Library search and matching
File export and format conversion
What clinical deployment requires
Patient identification and workflow
HL7/FHIR integration with LIS/EHR
Billing codes and reimbursement
Multi-site deployment and management
Clinician-friendly result interface
Regulatory audit trail (21 CFR Part 11)
Multi-vendor instrument support
Platform
How SpectraDx Works with NIR
01
Instrument Integration
Connect FOSS, Metrohm, and NeoSpectra NIR analyzers through standardized adapters. Support for serial, USB, and network-connected instruments.
Learn more →02
Calibration Management
Maintain and transfer chemometric models across NIR instruments. Automated recalibration validation, slope/bias correction, and model lifecycle tracking.
Learn more →03
Clinical ML Pipeline
Deploy PLS regression and classification models optimized for NIR’s broad, overlapping spectral features with proper preprocessing.
Learn more →04
Results Integration
Convert chemometric predictions into structured clinical results with HL7v2 or FHIR R4 output to hospital information systems.
Learn more →Resources
NIR Technical Resources
In-depth technical articles for NIR integration, clinical workflows, and regulatory compliance.
Deploy NIR-based diagnostics with SpectraDx
From NIR absorption spectra to clinical results. Non-invasive monitoring, pharmaceutical QC, and blood analysis — one platform.